|
KMID : 0191120090240040744
|
|
Journal of Korean Medical Science
2009 Volume.24 No. 4 p.744 ~ p.746
|
|
|
Successful Salvage Unrelated Umbilical Cord Blood Transplantation with Two Units After Engraftment Failure with Single Unit in Severe Aplastic Anemia
|
|
Lee Ji-Won
Kang Hyoung-Jin
Kim Eun-Kyung
Shin Hee-Young
Ahn Hyo-Seop
|
|
|
Abstract
|
|
|
|
Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Two-unit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.
|
|
|
KEYWORD
|
|
|
Anemia, Aplastic, Cord Blood Stem Cell Transplantation, Two-unit
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|